Impaired CD4 T cell activation due to reliance upon B cell-mediated costimulation in nonobese diabetic (NOD) mice.

@article{Noorchashm2000ImpairedCT,
  title={Impaired CD4 T cell activation due to reliance upon B cell-mediated costimulation in nonobese diabetic (NOD) mice.},
  author={Hooman Noorchashm and Daniel J. Moore and Lauren E. Noto and Negin Noorchashm and Amy J. Reed and Alison L. Reed and Howard K. Song and Raha Mozaffari and Anthony M Jevnikar and Clyde F. Barker and Abderrahim Naji},
  journal={Journal of immunology},
  year={2000},
  volume={165 8},
  pages={4685-96}
}
Diabetes in nonobese diabetic (NOD) mice results from the activation of I-A(g7)-restricted, islet-reactive T cells. This study delineates several characteristics of NOD CD4 T cell activation, which, independent of I-A(g7), are likely to promote a dysregulated state of peripheral T cell tolerance. NOD CD4 T cell activation was found to be resistant to antigenic stimulation via the TCR complex, using the progression of cell division as a measure. The extent of NOD CD4 T cell division was highly… CONTINUE READING

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