Impaired Bacillus Calmette-Guérin cellular immune response in HIV-exposed, uninfected infants.

  title={Impaired Bacillus Calmette-Gu{\'e}rin cellular immune response in HIV-exposed, uninfected infants.},
  author={Ta{\'i}s Nitsch Mazzola and Marcos Tadeu Nolasco da Silva and Beatriz Mariana Abramczuk and Yara Maria Franco Moreno and Simone Corte Batista Souza Lima and Tatiane Queiroz Zorzeto and Andr{\'e}a S Z Passeto and Maria Marluce dos Santos Vilela},
  volume={25 17},
OBJECTIVE To evaluate cell-mediated immune response to Bacillus Calmette-Guérin (BCG) vaccination in uninfected, HIV-1-exposed infants, comparing it with unexposed children. DESIGN It is designed as a cross-sectional study. METHODS BCG-specific lymphoproliferation and T-cell subsets (CD4(+), CD8(+) and TCR γδ(+)) by flow cytometry and interleukin-10, interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) concentration by ELISA were analyzed in HIV-exposed and unexposed infants. Whole… CONTINUE READING


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Robust gd T cell expansion in infants immunized at birth with BCG vaccine

  • TN Mazzola, MT Da Silva, YM Moreno, SC Lima, EF Carniel, AM Morcillo
  • Vaccine
  • 2007
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