Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice.

@article{Ma1998ImpairedBM,
  title={Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice.},
  author={Qing Ma and D Jones and Paul R. Borghesani and Rosalind A. Segal and Takashi Nagasawa and Tadamitsu Kishimoto and Roderick T Bronson and Timothy A. Springer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 16},
  pages={
          9448-53
        }
}
  • Q. Ma, D. Jones, +5 authors T. Springer
  • Published 1998
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
The chemokine stromal cell-derived factor 1, SDF-1, is an important regulator of leukocyte and hematopoietic precursor migration and pre-B cell proliferation. The receptor for SDF-1, CXCR4, also functions as a coreceptor for T-tropic HIV-1 entry. We find that mice deficient for CXCR4 die perinatally and display profound defects in the hematopoietic and nervous systems. CXCR4-deficient mice have severely reduced B-lymphopoiesis, reduced myelopoiesis in fetal liver, and a virtual absence of… Expand
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