Impaired Adipose Tissue Expansion Caused by LXR Activation is Associated with Insulin Resistance in HFD Mice

@inproceedings{Dong2016ImpairedAT,
  title={Impaired Adipose Tissue Expansion Caused by LXR Activation is Associated with Insulin Resistance in HFD Mice},
  author={Yueting Dong and Zhiye Xu and Ziyi Zhang and Xueyao Yin and Xihua Lin and Qianqian Pan and Hong Li and Fenping Zheng},
  year={2016}
}
Liver X receptors (LXR) are deemed as potential drug targets for atherosclerosis, whereas a role in adipose tissue expansion and its relation to insulin sensitivity remains unclear. To assess the metabolic effects of LXR activation, C57BL/6 mice on a high-fat diet (HFD) were treated with the dual LXRα/β agonist T0901317 (30 mg/kg per day) for 3 weeks. Differentiated 3T3-L1 was used for analysing the effect of T0901317 on glucose uptake.T0901317 reduced fat mass, accompanied by a massive fatty… CONTINUE READING

Figures from this paper.

References

Publications referenced by this paper.
SHOWING 1-10 OF 45 REFERENCES