Impacts of COX-1 gene polymorphisms on vascular outcomes in patients with ischemic stroke and treated with aspirin.

@article{Cao2014ImpactsOC,
  title={Impacts of COX-1 gene polymorphisms on vascular outcomes in patients with ischemic stroke and treated with aspirin.},
  author={L. Cao and Zhizhong Zhang and Wen Sun and W. Bai and Yumeng Zhang and Xiao-meng Wang and Biyang Cai and Xia Xie and Z. Duan and Qian-kun Cai and Dezhi Liu and Y. Xiong and Min-min Ma and Xinfeng Liu and Gelin Xu},
  journal={Gene},
  year={2014},
  volume={546 2},
  pages={
          172-6
        }
}
As the key point of function for aspirin to educe anti-platelet effects, cyclooxygenase-1 (COX-1) gene polymorphisms have long been suspected as a potential cause for aspirin nonresponsiveness. But this hypothesis has not been confirmed by large longitudinal studies. This study prospectively evaluated the impacts of COX-1 gene polymorphisms on stroke recurrence and other vascular events in a large cohort of Chinese patients with ischemic stroke and treated with aspirin. Between December 2009… Expand
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