Impact on antiviral resistance of E119V, I222L and R292K substitutions in influenza A viruses bearing a group 2 neuraminidase (N2, N3, N6, N7 and N9).

Abstract

OBJECTIVES While subtype-specific substitutions linked to neuraminidase (NA) inhibitor resistance are well described in human N1 and N2 influenza NAs, little is known about other NA subtypes. The aim of this study was to determine whether the R292K and E119V ± I222L substitutions could be associated with oseltamivir resistance in all group 2 NAs and had an… (More)

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@article{Gaymard2016ImpactOA, title={Impact on antiviral resistance of E119V, I222L and R292K substitutions in influenza A viruses bearing a group 2 neuraminidase (N2, N3, N6, N7 and N9).}, author={Alexandre Gaymard and Aymeric Charles-Dufant and Murielle Sabatier and J. C. Cortay and Emilie Frobert and Caroline Picard and Jean-sebastien Casalegno and Manuel Rosa-Calatrava and Olivier Ferraris and Martine Valette and Mich{\`e}le Ottmann and Bruno Lina and Vanessa Escuret}, journal={The Journal of antimicrobial chemotherapy}, year={2016}, volume={71 11}, pages={3036-3045} }