Impact of vitamin D and vitamin D receptor on the trophoblast survival capacity in preeclampsia

  title={Impact of vitamin D and vitamin D receptor on the trophoblast survival capacity in preeclampsia},
  author={Martina Hutabarat and Noroyono Wibowo and Barbara Obermayer-Pietsch and Berthold Huppertz},
  booktitle={PloS one},
BACKGROUND Preeclampsia and intra-uterine growth restriction (IUGR) are major health problems during pregnancy affecting both mother and child. Defective placental development and failure of trophoblast differentiation during pregnancy are important aspects in the pathogenesis of both syndromes. Recent studies have shown that autophagy is involved in the trophoblast survival capacity. As vitamin D has a central role in many cellular processes, we studied the relation of vitamin D and autophagy… CONTINUE READING


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