Impact of vitamin C on endothelial function and exercise capacity in patients with a Fontan circulation.

OBJECTIVE   To evaluate the impact of antioxidant therapy on functional health status in Fontan-palliated patients. Design.  Prospective, randomized, double-blind, placebo-controlled trial. PATIENTS   Fifty-three generally asymptomatic Fontan patients. INTERVENTIONS   Patients were randomized to receive either high-dose ascorbic acid (vitamin C) or… CONTINUE READING