Impact of variation in the BDNF gene on social stress sensitivity and the buffering impact of positive emotions: Replication and extension of a gene–environment interaction

@article{Winkel2014ImpactOV,
  title={Impact of variation in the BDNF gene on social stress sensitivity and the buffering impact of positive emotions: Replication and extension of a gene–environment interaction},
  author={Mark van Winkel and Frenk Peeters and Ruud Van Winkel and Gunter R L Kenis and Dina Collip and Nicole Geschwind and Nele Jacobs and Catherine A. Derom and Evert Thiery and Jim van Os and Inez Myin-Germeys and Marieke Wichers},
  journal={European Neuropsychopharmacology},
  year={2014},
  volume={24},
  pages={930-938}
}
A previous study reported that social stress sensitivity is moderated by the brain-derived-neurotrophic-factor(Val66Met) (BDNF rs6265) genotype. Additionally, positive emotions partially neutralize this moderating effect. The current study aimed to: (i) replicate in a new independent sample of subjects with residual depressive symptoms the moderating effect of BDNF(Val66Met) genotype on social stress sensitivity, (ii) replicate the neutralizing impact of positive emotions, (iii) extend these… CONTINUE READING
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