Impact of type-I-interferon on monocyte subsets and their differentiation to dendritic cells: An in vivo and ex vivo study in multiple sclerosis patients treated with interferon-beta

@article{Bergh2004ImpactOT,
  title={Impact of type-I-interferon on monocyte subsets and their differentiation to dendritic cells: An in vivo and ex vivo study in multiple sclerosis patients treated with interferon-beta},
  author={Florian Then Bergh and Farshid Dayyani and Loems Ziegler-Heitbrock},
  journal={Journal of Neuroimmunology},
  year={2004},
  volume={146},
  pages={176-188}
}
In addition to CD14++ "classical" monocytes, human peripheral blood contains CD14+CD16+ "pro-inflammatory" monocytes, which may be influenced by IFNb treatment. By fluorescence activated cell sorting (FACS) analysis, 94 multiple sclerosis (MS) patients revealed normal absolute and relative numbers of both monocyte populations (71 untreated, 23 IFNb-treated). In IFNb-treated patients, CD14+CD16+ monocytes consistently expressed higher CD14, confirmed in 16 patients analyzed longitudinally. Ex… CONTINUE READING

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