Impact of tumor progression on cancer incidence curves.

  title={Impact of tumor progression on cancer incidence curves.},
  author={E. Georg Luebeck and Kit Curtius and Jihyoun Jeon and William D. Hazelton},
  journal={Cancer research},
  volume={73 3},
Cancer arises through a multistage process, but it is not fully clear how this process influences the age-specific incidence curve. Studies of colorectal and pancreatic cancer using the multistage clonal expansion (MSCE) model have identified two phases of the incidence curves. One phase is linear, beginning about age of 60 years, suggesting that at least two rare rate-limiting mutations occur before clonal expansion of premalignant cells. A second phase is exponential, seen in early-onset… CONTINUE READING


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