Impact of tumor biology, particularly triple-negative status, on response to pre-operative sequential, dose-dense epirubicin, cyclophosphamide followed by docetaxel in breast cancer.

@article{Warm2010ImpactOT,
  title={Impact of tumor biology, particularly triple-negative status, on response to pre-operative sequential, dose-dense epirubicin, cyclophosphamide followed by docetaxel in breast cancer.},
  author={M Warm and R Kates and Em Grosse-Onnebrink and Mariam Alexandra Stoff-Khalili and M Hoopmann and P Mallmann and A Thomas and N Harbeck},
  journal={Anticancer research},
  year={2010},
  volume={30 10},
  pages={4251-9}
}
  • M Warm, R Kates, +5 authors N Harbeck
  • Published 2010 in Anticancer research
BACKGROUND The central objective of this study was to determine the predictive impact of several established tumor biological factors (PgR, ER, HER2 and Ki-67) on response to pre-operative chemotherapy in primary breast cancer. PATIENTS AND METHODS 59 primary M0 breast cancer patients received pre-operative sequential dose-dense epirubicin and cyclophosphamide followed by docetaxel (19 patients at dosage 100 mg/m(2), 40 patients at 75 mg/m(2)). RESULTS Pathological complete remission (pCR… CONTINUE READING