Impact of trisomy on fertility and meiosis in male mice.

  title={Impact of trisomy on fertility and meiosis in male mice.},
  author={Muriel T. Davisson and E. C. Akeson and Christian Schmidt and Barbara Harris and Jordan Farley and Mary Ann Handel},
  journal={Human reproduction},
  volume={22 2},
BACKGROUND Chromosomal abnormalities frequently are associated with impairment or arrest of spermatogenesis in mammals but are compatible with fertility in female carriers of the same anomaly. In the case of trisomy, mice have extra genomic DNA as well as the chromosomal abnormality, usually present as an extra, unpaired chromosome. Thus, impairment of spermatogenesis in trisomic males could be due to the presence of extra genomic material (i.e. triplicated genes) or due to the chromosomal… CONTINUE READING


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