Impact of thyroid disease on testicular function

@article{Vignera2017ImpactOT,
  title={Impact of thyroid disease on testicular function},
  author={Sandro La Vignera and Roberto Vita and Rosita Angela Condorelli and Laura Maria Mongio{\`i} and Silvia Presti and Salvatore Benvenga and Aldo Eugenio Calogero},
  journal={Endocrine},
  year={2017},
  volume={58},
  pages={397-407}
}
IntroductionTestis was considered unresponsive to thyroid hormone for a long time. However, like in animals, the presence of thyroid hormone receptors in different testicular cell types was demonstrated also in humans. Accordingly, thyrotoxicosis and hypothyroidism have remarkable effects on testicular function and more extensively on fertility.ReviewThyrotoxicosis and hypothyroidism are associated with changes affecting the endocrine, sexual, or reproductive functions. Particularly, compared… 

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References

SHOWING 1-10 OF 92 REFERENCES

Clinical implications of altered thyroid status in male testicular function.

The current review aims at presenting an updated picture of recent clinical data about the role of thyroid hormones in male gonadal function, which can be in part due to the lack of well-controlled clinical studies.

Thyroid hormone and male gonadal function.

The potential of thyroid hormone in the modulation of male reproductive functions was not determined for several years because of the apparent clinical irrelevance of signs and symptoms related to male gonadal function compared with the systemic effects of hyper- and hypothyroidism.

Thyroid function and human reproductive health.

Via its interaction in several pathways, normal thyroid function is important to maintain normal reproduction. In both genders, changes in SHBG and sex steroids are a consistent feature associated

The role of thyroid hormone in testicular development and function.

The current review aims at presenting an updated picture of the recent advances made regarding the role of thyroid hormones in male gonadal function.

New insights for male infertility revealed by alterations in spermatic function and differential testicular expression of thyroid-related genes

The observed alterations in spermatic production and function and in the expression of the TH receptor, deiodinase, and the TH transporter are suggestive of TH participation in sPermatogenesis in adulthood in adulthood.

Is there a role for thyroid hormone on spermatogenesis?

This review has attempted to address the role of thyroid hormone in the regulation of spermatogenesis, emphasizing recent data that suggest its involvement in germ cells differentiation and survival.

Testicular function in hyperthyroidism.

The results of this study indicate that hyperthyroid men may have abnormalities in their hypothalamic-pituitary-testicular axes.

Hypothyroidism has an adverse effect on human spermatogenesis: a prospective, controlled study.

Investigation of the impact of hypothyroidism on human spermatogenesis and different sperm function tests found Morphology is the only sperm parameter that is significantly affected and Motility was also decreased before treatment in comparison with controls, and improved after treatment.

Abnormal testicular function in men with primary hypothyroidism.

Thyroid hormones and thyroid antibodies in infertile males.

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