Impact of the non-cellular tumor microenvironment on metastasis: potential therapeutic and imaging opportunities.

@article{Cretu2007ImpactOT,
  title={Impact of the non-cellular tumor microenvironment on metastasis: potential therapeutic and imaging opportunities.},
  author={Alexandra Cretu and P. C. Brooks},
  journal={Journal of cellular physiology},
  year={2007},
  volume={213 2},
  pages={391-402}
}
Evidence is accumulating that the malignant phenotype of a given tumor is dependent not only on the intrinsic characteristics of tumor cells, but also on the cooperative interactions of non-neoplastic cells, soluble secreted factors and the non-cellular solid-state ECM network that comprise the tumor microenvironment. Given the ability of the tumor microenvironment to regulate the cellular phenotype, recent efforts have focused on understanding the molecular mechanisms by which cells sense… CONTINUE READING

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