Impact of the interaction of R207910 with rifampin on the treatment of tuberculosis studied in the mouse model.

@article{Lounis2008ImpactOT,
  title={Impact of the interaction of R207910 with rifampin on the treatment of tuberculosis studied in the mouse model.},
  author={Nacer Lounis and Tom Gevers and Joke Van den Berg and Koen Andries},
  journal={Antimicrobial agents and chemotherapy},
  year={2008},
  volume={52 10},
  pages={3568-72}
}
New drugs are needed to shorten the duration of tuberculosis treatment. R207910, a diarylquinoline, is very active against Mycobacterium tuberculosis both in vitro and in mice. In healthy volunteers, the coadministration of R207910 and rifampin induced the increased metabolism of R207910, resulting in a 50% reduction in the level of R207910 exposure. We… CONTINUE READING