Impact of the immunological synapse on T cell signaling.

  title={Impact of the immunological synapse on T cell signaling.},
  author={Michael L. Dustin},
  journal={Results and problems in cell differentiation},
T cell activation requires interactions of T cell antigen receptors and peptides presented by major histocompatibility complex molecules in an adhesive junction between the T cell and antigen-presenting cell (APC). Stable junctions with bull's-eye supramolecular activation clusters have been defined as immunological synapses (IS). These structures maintain T cell-APC interaction and allow directed secretion. T cells can also be activated by asymmetric hemisynapses (HS) that allow migration… CONTINUE READING

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