Impact of the Timing of Metoprolol Administration During STEMI on Infarct Size and Ventricular Function.

  title={Impact of the Timing of Metoprolol Administration During STEMI on Infarct Size and Ventricular Function.},
  author={Jos{\'e} Manuel Garc{\'i}a-Ru{\'i}z and Rodrigo Fern{\'a}ndez-Jim{\'e}nez and Ana Garc{\'i}a-{\'A}lvarez and Gonzalo E. Pizarro and Carlos Gal{\'a}n-Arriola and Leticia Fern{\'a}ndez-Friera and A Alonso Mateos and Mario Nu{\~n}o-Ayala and Jaume Aguero and Javier Sanchez-Gonz{\'a}lez and Jaime Garc{\'i}a-Prieto and Beatriz L{\'o}pez-Melgar and Pedro Mart{\'i}nez-Tenorio and Gonzalo J. L{\'o}pez-Mart{\'i}n and Angel Ramos Mac{\'i}as and Braulio P{\'e}rez-Asenjo and Jos{\'e} {\'A}ngel Cabrera and Antonio Fern{\'a}ndez-Ort{\'i}z and Valentin Fuster and Borja Ib{\'a}{\~n}ez},
  journal={Journal of the American College of Cardiology},
  volume={67 18},
BACKGROUND Pre-reperfusion administration of intravenous (IV) metoprolol reduces infarct size in ST-segment elevation myocardial infarction (STEMI). OBJECTIVES This study sought to determine how this cardioprotective effect is influenced by the timing of metoprolol therapy having either a long or short metoprolol bolus-to-reperfusion interval. METHODS We performed a post hoc analysis of the METOCARD-CNIC (effect of METOprolol of CARDioproteCtioN during an acute myocardial InfarCtion) trial… CONTINUE READING
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  • J Garcia-Prieto, I García-Lumar, M Gomez-Parrizas
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