Impact of the Ki-67 proliferation index on response to peptide receptor radionuclide therapy

@article{Ezziddin2010ImpactOT,
  title={Impact of the Ki-67 proliferation index on response to peptide receptor radionuclide therapy},
  author={Samer Ezziddin and Martin Opitz and Mared Attassi and Kim Biermann and Amir Hossein Nodehi Sabet and Stefan Guhlke and Holger A Brockmann and Winfried W Willinek and Eva Wardelmann and Hans-J{\"u}rgen Biersack and Hojjat Ahmadzadehfar},
  journal={European Journal of Nuclear Medicine and Molecular Imaging},
  year={2010},
  volume={38},
  pages={459-466}
}
The role of the Ki-67 tumour proliferation index (PI) in predicting the efficacy of peptide receptor radionuclide therapy (PRRT) in gastroenteropancreatic tumours (GEP-NET) remains undetermined. This single-centre analysis focused on the potential therapeutic impact of this immunohistochemical parameter. A total of 81 consecutive GEP-NET patients treated with 177Lu-DOTA-octreotate (mean activity of 7.9 GBq per cycle, usually four treatment cycles at standard intervals of 3 months) were… CONTINUE READING

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