Impact of the K24N mutation on the transactivation domain of p53 and its binding to murine double-minute clone 2.

@article{Zhan2013ImpactOT,
  title={Impact of the K24N mutation on the transactivation domain of p53 and its binding to murine double-minute clone 2.},
  author={Yingqian Ada Zhan and Hongwei Wu and Anne T Powell and Gary W. Daughdrill and F. Marty Ytreberg},
  journal={Proteins},
  year={2013},
  volume={81 10},
  pages={1738-47}
}
The level of the p53 transcription factor is negatively regulated by the E3 ubiquitin ligase murine double-minute clone 2 (MDM2). The interaction between p53 and MDM2 is essential for the maintenance of genomic integrity for most eukaryotes. Previous structural studies revealed that MDM2 binds to p53 transactivation domain (p53TAD) from residues 17 to 29. The K24N mutation of p53TAD changes a lysine at position 24 to an asparagine. This mutation occurs naturally in the bovine family and is also… CONTINUE READING
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