Impact of the CYP2D6 ultra-rapid metabolizer genotype on doxepin pharmacokinetics and serotonin in platelets

@article{Kirchheiner2005ImpactOT,
  title={Impact of the CYP2D6 ultra-rapid metabolizer genotype on doxepin pharmacokinetics and serotonin in platelets},
  author={Julia Kirchheiner and H. B. Henckel and Leonora Franke and Ingolf Meineke and Mladen Vassilev Tzvetkov and Ralf Uebelhack and Ivar Roots and J{\"u}rgen Brockm{\"o}ller},
  journal={Pharmacogenetics and Genomics},
  year={2005},
  volume={15},
  pages={579-587}
}
Introduction CYP2D6 gene duplication causing ultrafast metabolism is one reason for failure in responding to CYP2D6-metabolized antidepressants. We studied the effect of the CYP2D6 duplication genotype on doxepin pharmacokinetics and platelet serotonin uptake and concentrations. Methods Pharmacokinetics of trans (E)- and cis (Z)-doxepin and N-desmethyldoxepin were analyzed after a single dose of 75 mg doxepin in 11 ultrafast metabolizers (UM), 11 extensive metabolizers (EM) and 3 poor… 

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