Impact of the CYP2D6 genotype on post-operative intravenous oxycodone analgesia.

@article{Zwisler2010ImpactOT,
  title={Impact of the CYP2D6 genotype on post-operative intravenous oxycodone analgesia.},
  author={Stine Thorhauge Zwisler and Thomas Peter Enggaard and Soeren Mikkelsen and Kim Brosen and S\oren Hein Sindrup},
  journal={Acta anaesthesiologica Scandinavica},
  year={2010},
  volume={54 2},
  pages={232-40}
}
BACKGROUND Oxycodone is a semi-synthetic opioid with a mu-receptor agonist-mediated effect in several pain conditions, including post-operative pain. Oxycodone is metabolized to its active metabolite oxymorphone by O-demethylation via the polymorphic CYP2D6. The aim of this study was to investigate whether CYP2D6 poor metabolizers (PMs) yield the same analgesia post-operatively from intravenous oxycodone as extensive metabolizers (EMs). METHODS Two hundred and seventy patients undergoing… CONTINUE READING

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