Impact of the COMT Val<ce:sup loc=post>108/158</ce:sup> Met and DAT genotypes on prefrontal function in healthy subjects

@article{Cald2007ImpactOT,
  title={Impact of the COMT Val<ce:sup loc=post>108/158</ce:sup> Met and DAT genotypes on prefrontal function in healthy subjects},
  author={Xavier Cald{\'u} and Pere Vendrell and David Bartr{\'e}s-Faz and Inmaculada Clemente and N{\'u}ria Bargall{\'o} and Mar{\'i}a {\'A}ngeles Jurado and Josep Maria Serra-Grabulosa and Carme Junqu{\'e}},
  journal={NeuroImage},
  year={2007},
  volume={37},
  pages={1437-1444}
}
Two limiting factors of dopamine activity are the catechol-o-methyltransferase (COMT) and the dopamine transporter (DAT), which terminate dopamine activity by degradation and uptake, respectively. Genetic variants of COMT and DAT have been related to the enzymatic activity and protein availability, respectively. The Met allele of the COMT Val108/158 Met polymorphism has been associated to lower enzymatic activity and the 9-repeat allele of the DAT 40 base-pair (bp) variable number of tandem… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 79 extracted citations

Genetic polymorphisms of 5-HTT and DAT but not COMT differentially affect verbal and visuospatial working memory functioning

European Archives of Psychiatry and Clinical Neuroscience • 2012
View 5 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 57 references

Additive effects of genetic variation in dopamine regulating genes on working memory cortical activity in human brain.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2006
View 17 Excerpts
Highly Influenced

Effect of COMT Val 108 / 158 Metgenotypeonfrontal lobefunctionandrisk forschizophrenia

M. F. Egan, T. E. Goldberg, +5 authors D. R. Weinberger
Proc . Natl . Acad . Sci . • 2001
View 15 Excerpts
Highly Influenced

Effect of COMT ValMetgenotypeonfrontal lobefunctionandrisk forschizophrenia

M. F. Egan, T. E. Goldberg, +5 authors D. R. Weinberger
Proc. Natl. Acad. Sci • 2001
View 20 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…