Impact of the C2/C6 ratio of high-molecular-weight hydroxyethyl starch on pharmacokinetics and blood coagulation in pigs.

@article{Schramm2007ImpactOT,
  title={Impact of the C2/C6 ratio of high-molecular-weight hydroxyethyl starch on pharmacokinetics and blood coagulation in pigs.},
  author={Sebastian Schramm and Caroline Thyes and Philippe Frascarolo and Thierry Buclin and Marco Burki and Andreas Fisch and M A Burmeister and Lars M. Asmis and Donat R Spahn},
  journal={Anesthesiology},
  year={2007},
  volume={107 3},
  pages={442-51}
}
BACKGROUND High-molecular-weight, low-substituted hydroxyethyl starch (HES) may not affect blood coagulation more than low-molecular-weight, low-substituted HES. The authors assessed in vivo the effect of a lowered C2/C6 ratio on pharmacokinetic characteristics and the impact on blood coagulation of high-molecular-weight, low-substituted HES. METHODS A prospective, randomized, parallel study in 30 pigs compared HES 650/0.42/2.8 with HES 650/0.42/5.6. Before, during, and after infusion of 30… CONTINUE READING