Impact of surfactants on the crystal growth of amorphous celecoxib.

@article{MosqueraGiraldo2014ImpactOS,
  title={Impact of surfactants on the crystal growth of amorphous celecoxib.},
  author={Laura Isabel Mosquera-Giraldo and Niraj S. Trasi and Lynne S Taylor},
  journal={International journal of pharmaceutics},
  year={2014},
  volume={461 1-2},
  pages={251-7}
}
The purpose of this study was to investigate the impact of surfactants on the rate of crystal growth of amorphous celecoxib, both in the presence and absence of a polymer. Celecoxib is a poorly water-soluble non-steroidal anti-inflammatory drug. Such compounds may be formulated as amorphous solid dispersions to improve bioavailability, and solid dispersions can contain both a surfactant and a polymer. While the impact of polymers on crystal growth rates has been studied, the effect of… CONTINUE READING

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