Impact of superantigenic molecules on central nervous system function.

@article{UrbachRoss2009ImpactOS,
  title={Impact of superantigenic molecules on central nervous system function.},
  author={Daniella Urbach-Ross and Alexander W. Kusnecov},
  journal={Frontiers in bioscience},
  year={2009},
  volume={14},
  pages={
          4416-26
        }
}
Superantigens (SAgs) activate the immune system by stimulating massive proliferation of T cells in a major histocompatibility complex (MHC)-dependent manner. This excessive increase in T cells results in the release of cytokines such as interleukin-2 (IL-2), interferon-gamma (IFNgamma), and tumor necrosis factor-alpha (TNFa). As an adaptive feedback mechanism, SAgs can also activate the hypothalamic pituitary adrenal (HPA) axis by stimulating the release of corticotropin releasing hormone (CRH… 
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