Impact of study design on the evaluation of inhaled and intranasal corticosteroids' effect on hypothalamic-pituitary-adrenal axis function, part I: general overview of HPA axis study design.

@article{Fan2013ImpactOS,
  title={Impact of study design on the evaluation of inhaled and intranasal corticosteroids' effect on hypothalamic-pituitary-adrenal axis function, part I: general overview of HPA axis study design.},
  author={Ying Fan and Lian Ma and Jennifer R. Pippins and Susan L. Limb and Yun Xu and Chandrahas G. Sahajwalla},
  journal={Journal of pharmaceutical sciences},
  year={2013},
  volume={102 10},
  pages={3513-27}
}
Inhaled and intranasal corticosteroids (ICS and INS) are among the mainstays of the treatment for asthma and allergic rhinitis, respectively, and also carry the potential to suppress the hypothalamic-pituitary-adrenal (HPA) axis. Several important factors affect the interpretability of trials investigating the impact of ICS and INS on the HPA axis. This paper reviews 106 published clinical trials, peer-reviewed articles, and New Drug Application reviews of approved ICS and INS, using MEDLINE… CONTINUE READING
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