Impact of stimulatory pathways on adipogenesis and HIV-therapy associated lipoatrophy.

OBJECTIVE Current understanding of adipogenesis derives mainly from studies with in vitro cell culture systems with divergent experimental requirements. We aimed to investigate the discrepancy between the anti-adipogenic effects of the HIV protease-inhibitor indinavir (IDV) in vitro and the lack of evidence that IDV inhibits adipogenesis in humans. DESIGN… CONTINUE READING