Impact of spironolactone on vascular, myocardial, and functional parameters in untreated patients with a hypertensive response to exercise.

@article{Hare2013ImpactOS,
  title={Impact of spironolactone on vascular, myocardial, and functional parameters in untreated patients with a hypertensive response to exercise.},
  author={James L. Hare and James E Sharman and Rodel L Leano and Carly E Jenkins and Leah Wright and Thomas H Marwick},
  journal={American journal of hypertension},
  year={2013},
  volume={26 5},
  pages={691-9}
}
BACKGROUND Although a hypertensive response to exercise (HRE) is associated with cardiac risk and masked hypertension (MHT), its mechanisms and appropriate treatment remain unclear. We investigated spironolactone as a treatment for abnormal vascular and myocardial stiffness in HRE. METHODS In this randomized, double-blind, placebo-controlled study of 115 patients (54 ± 9 years, 57% men) with an HRE (≥210/105 mm Hg in men; ≥190/105 mm Hg in women) but no prior history of hypertension or… CONTINUE READING
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