Impact of spironolactone on vascular, myocardial, and functional parameters in untreated patients with a hypertensive response to exercise.


BACKGROUND Although a hypertensive response to exercise (HRE) is associated with cardiac risk and masked hypertension (MHT), its mechanisms and appropriate treatment remain unclear. We investigated spironolactone as a treatment for abnormal vascular and myocardial stiffness in HRE. METHODS In this randomized, double-blind, placebo-controlled study of 115… (More)
DOI: 10.1093/ajh/hpt008