Impact of smoking on the expression of claudins in lung carcinoma.

@article{Merikallio2011ImpactOS,
  title={Impact of smoking on the expression of claudins in lung carcinoma.},
  author={Heta M Merikallio and Riitta L. Kaarteenaho and Paavo K P{\"a}{\"a}kk{\"o} and Siri T. Lehtonen and Pasi Hirvikoski and Riitta M{\"a}kitaro and Terttu H Harju and Ylermi M Soini},
  journal={European journal of cancer},
  year={2011},
  volume={47 4},
  pages={620-30}
}
RATIONALE Tight junctions regulate the paracellular permeability and orientation of cells and claudins are key components of tight junctions. OBJECTIVES To study the influence of cigarette smoke on claudin expression in vitro and in lung cancer patients. METHODS We studied the effect of smoking on claudin expression by exposing a bronchial cell line (BEAS-2B) and two carcinoma cell lines (SK-LU1 and SK-MES1) to tobacco smoke for 48 h and analysed their claudin mRNA expression. The relation… CONTINUE READING
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