3,260 Citations
Sleep as a Mediator of the Relationship between Socioeconomic Status and Health: A Hypothesis
- MedicineAnnals of the New York Academy of Sciences
- 1999
Results indicate that sleep loss can increase the “allostatic load” and facilitate the development of chronic conditions, such as obesity, diabetes, and hypertension, which have an increased prevalence in low SES groups.
Partial sleep restriction modulates secretory activity of thyrotropic axis in healthy men
- Biology, MedicineJournal of sleep research
- 2013
Results indicate profound alterations in the secretory activity of the thyrotropic axis after 2 days of sleep restriction to ~4 h, suggesting that acute partial sleep loss impacts endocrine homeostasis, with potential consequences for health and wellbeing.
Sleep loss alters basal metabolic hormone secretion and modulates the dynamic counterregulatory response to hypoglycemia.
- Medicine, BiologyThe Journal of clinical endocrinology and metabolism
- 2007
Immediate perturbations in the dynamic regulation of energy metabolism caused by acute sleep curtailment may contribute to the association between chronic sleep loss and metabolic disorders.
The ‘ Sleep Debt Study ’ : 6 days with 4-h bedtimes
- Medicine, Biology
- 2008
Sleep is an important modulator of neuroendocrine function and glucose metabolism in children as well as in adults. In recent years, sleep curtailment has become a hallmark of modern society with…
Adverse effects of two nights of sleep restriction on the hypothalamic-pituitary-adrenal axis in healthy men.
- Medicine, BiologyThe Journal of clinical endocrinology and metabolism
- 2014
The impact of sleep loss on hypothalamic-pituitary-adrenal activity is dependent on time of day, and sleep restriction was not associated with higher perceived stress but resulted in an increase in appetite that was correlated with the increase in total cortisol.
Adverse effects of modest sleep restriction on sleepiness, performance, and inflammatory cytokines.
- Medicine, PsychologyThe Journal of clinical endocrinology and metabolism
- 2004
It is concluded that in young men and women, modest sleep loss is associated with significant sleepiness, impairment of psychomotor performance, and increased secretion of proinflammatory cytokines.
Timing Modulates the Effect of Sleep Loss on Glucose Homeostasis.
- Biology, MedicineThe Journal of clinical endocrinology and metabolism
- 2019
Although sleep deprivation acutely reduced insulin sensitivity irrespective of its nocturnal timing, sleep loss in the early morning compromised α-cell and hypothalamic-pituitary-adrenal axis activity to a greater extent than sleep lossin the first half of the night, suggesting that the timing of sleep restriction can partly potentiate its deleterious metabolic effects.
Effects of sleep fragmentation on glucose metabolism in normal subjects.
- Medicine, BiologyChest
- 2010
Fragmentation of sleep across all stages is associated with a decrease in S(I) and S(G), and increases in sympathetic nervous system and adrenocortical activity likely mediate the adverse metabolic effects of poor sleep quality.
Sleep and metabolic function
- Medicine, BiologyPflügers Archiv - European Journal of Physiology
- 2011
The data available in the literature highlight the importance of getting enough good sleep for metabolic health, and how obstructive sleep apnea affects glucose metabolism and the beneficial impact of its treatment, the continuous positive airway pressure is discussed.
References
SHOWING 1-10 OF 35 REFERENCES
Sleep loss results in an elevation of cortisol levels the next evening.
- BiologySleep
- 1997
It is concluded that even partial acute sleep loss delays the recovery of the HPA from early morning circadian stimulation and is thus likely to involve an alteration in negative glucocorticoid feedback regulation.
Changes in cortisol and growth hormone secretion during nocturnal sleep in the course of aging.
- Medicine, BiologyThe journals of gerontology. Series A, Biological sciences and medical sciences
- 1996
BACKGROUND
One current hypothesis of biological aging proposes that aging results from the deterioration of neuroendocrine functions. Sleep dependent growth hormone (GH) secretion is diminished in…
Sleep science : integrating basic research and clinical practice
- Biology, Psychology
- 1997
The neurobiology of sleep and sleep disorders not yet known and translation to therapy: melatonin, J.M. Krueger and F. Obal Jr.
Cumulative sleepiness, mood disturbance, and psychomotor vigilance performance decrements during a week of sleep restricted to 4-5 hours per night.
- PsychologySleep
- 1997
It is suggested that cumulative nocturnal sleep debt had a dynamic and escalating analog in cumulative daytime sleepiness and that asymptotic or steady-state sleepiness was not achieved in response to sleep restriction.
Feast and Famine: Critical Role of Glucocorticoids with Insulin in Daily Energy Flow
- Biology, MedicineFrontiers in Neuroendocrinology
- 1993
The hypothesis proposed in this review is that normal diurnal rhythms in the hypothalamic-pituitary-adrenal (HPA) axis are highly regulated by activity in medial hypothalamic nuclei to effect an…
Performance and mood during and after gradual sleep reduction.
- PsychologyPsychophysiology
- 1977
It was concluded that 6–8 months of gradual sleep restriction, down to 4.5–5.5 hrs per night, does not result in behavioral effects measurable by the instruments used, and subjective fatigue appears to be the limiting factor in determining tolerability of gradualSleep restriction.
Effects of gender and age on the levels and circadian rhythmicity of plasma cortisol.
- Biology, MedicineThe Journal of clinical endocrinology and metabolism
- 1996
There are marked gender-specific effects of aging on the levels and diurnal variation of human adrenocorticotropic activity, consistent with the hypothesis of the "wear and tear" of lifelong exposure to stress.
Persistence of the circadian thyrotropin rhythm under constant conditions and after light-induced shifts of circadian phase.
- Biology, MedicineThe Journal of clinical endocrinology and metabolism
- 1994
TSH levels and body temperature rhythms were substantially shifted, by an equivalent amount, in response to three consecutive nightly exposures to bright light, demonstrating that both the output of the human circadian pacemaker and the inhibitory effect of sleep contribute to the regulation of TSH secretion.
Insufficient sleep in the general population
- Psychology, MedicineNeurophysiologie Clinique/Clinical Neurophysiology
- 1996
Changes in insulin sensitivity, glucose effectiveness, and B-cell function in regularly exercising subjects.
- MedicineMetabolism: clinical and experimental
- 1995