Impact of simultaneous stimulation of 5-lipoxygenase and myeloperoxidase in human neutrophils.

Abstract

Human neutrophil 5-lipoxygenase (5-LOX) oxidizes arachidonic acid (AA) to 5S-hydro(pero)xy-6E,8Z,11Z, 14Z-eicosatetraenoic acid (5-H(p)ETE) and leukotriene (LT)A4, which is further converted to the chemoattractant LTB4. These cells contain also the heme enzyme myeloperoxidase (MPO) producing several potent oxidants such as hypochlorous acid (HOCl… (More)
DOI: 10.1016/j.plefa.2016.02.001

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