Impact of simulated microgravity on cell cycle control and cytokine release by U937 cells.

@article{Maier2006ImpactOS,
  title={Impact of simulated microgravity on cell cycle control and cytokine release by U937 cells.},
  author={Jeanette A. M. Maier},
  journal={International journal of immunopathology and pharmacology},
  year={2006},
  volume={19 2},
  pages={279-86}
}
Previous experiments from flight- and ground-based model systems indicate unexpected alterations of human leukocytes, leading to growth retardation and depression of mitogenic activation. The response of myelomonocytic U937 cells to simulated microgravity was therefore investigated. To this purpose, U937 cells were cultured in the NASA-developed bioreactor Rotating Wall Vessel (RWV) as a device to simulate microgravity on earth. No apoptosis was detected, in part because of the up-regulation of… CONTINUE READING