Impact of siderophore production on Pseudomonas aeruginosa infections in immunosuppressed mice.

@article{Takase2000ImpactOS,
  title={Impact of siderophore production on Pseudomonas aeruginosa infections in immunosuppressed mice.},
  author={Hiromichi Takase and Hironobu Nitanai and Kiichi Hoshino and Tsuyoshi Otani},
  journal={Infection and immunity},
  year={2000},
  volume={68 4},
  pages={1834-9}
}
Pseudomonas aeruginosa produces siderophores, pyoverdin and pyochelin, for high-affinity iron uptake. To investigate their contribution to P. aeruginosa infections, we constructed allelic exchange mutants from strain PAO1 which were deficient in producing one or both of the siderophores. When inoculated into the calf muscles of immunosuppressed mice, pyochelin-deficient and pyoverdin-deficient mutants grew and killed the animals as efficiently as PAO1. In contrast, the pyochelin- and pyoverdin… CONTINUE READING

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The structure of pyoverdinePa, the siderophore of Pseudomonas aeruginosa

  • S. Wendenbaum, P. Demange, A. Dell, J. M. Meyer, M. A. Abdallah
  • 1983
Highly Influential
6 Excerpts

Siderophore-mediated iron transport in Pseudomonas aeruginosa, p. 371–383

  • K. Poole, C. Dean, +4 authors L. Kilburn
  • 1996
Highly Influential
5 Excerpts

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