Impact of sex differences and gender specificity on behavioral characteristics and pathophysiology of neurodegenerative disorders

@article{Ullah2019ImpactOS,
  title={Impact of sex differences and gender specificity on behavioral characteristics and pathophysiology of neurodegenerative disorders},
  author={Mohammad Fahad Ullah and Aamir Ahmad and Showket Hussain Bhat and Faisel Mohammed Abu-Duhier and George E. Barreto and Ghulam Md. Ashraf},
  journal={Neuroscience \& Biobehavioral Reviews},
  year={2019},
  volume={102},
  pages={95-105}
}
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This chapter aims to outline sex differences in key homeostatic domains thought to be associated with the pathophysiology of aging, often proposed as biomarkers of aging and age-related disease states with regards to the gonadal and adrenal endocrine systems and immune function.
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The hormonal hypothesis as well as other mechanisms will be examined and discussed in the light of the most recent epigenetic findings in the field, as the concept that epigenetics is the unifying mechanism in explaining gender-specific differences is increasingly emerging.
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Hearing impairment was associated with cognitive impairment among older people, and this association may be attenuated by a more feminine GS, according to multivariable models including sex and gender as exposure variables.
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Findings indicate potential contributions of sex and education to the presentation of BPSD and models for tailoring therapeutic programs to individual AD patients according to these factors are warranted.
Dysmetabolism and Neurodegeneration: Trick or Treat?
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The role of insulin in the brain is focused on, with special attention to its function in the regulation of brain glucose metabolism, feeding, and cognition, with a particular emphasis on the evidence observed in animal models of dysmetabolism induced by hypercaloric diets.
Age‐related hearing loss: Why we need to think about sex as a biological variable
TLDR
The evidence is reviewed why it is necessary to consider sex as a biological variable (SABV) when investigating the etiology of ARHL, which is frequency‐specific and modulated by SABV.
Resveratrol Derivatives as Potential Treatments for Alzheimer’s and Parkinson’s Disease
TLDR
A review article aims to discuss how resveratrol derivatives could represent viable molecules in the search for new drugs for the treatment of AD and PD.
Uric Acid as a Potential Peripheral Biomarker for Disease Features in Huntington’s Patients
TLDR
It is suggested that decreased levels of UA in the brains of HD patients can be reflected in peripheral fluids, with salivary measures of UA particularly offering significant promise as a potentially relevant, non-invasive biomarker of disease symptoms and burden.
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