Impact of schedule duration on head and neck radiotherapy: accelerated tumor repopulation versus compensatory mucosal proliferation.

PURPOSE To determine how modelled maximum tumor control rates, achievable without exceeding mucositis tolerance (tcp(max-early)) vary with schedule duration for head and neck squamous cell carcinoma (HNSCC). METHODS AND MATERIALS Using maximum-likelihood techniques, we have fitted a range of tcp models to two HNSCC datasets (Withers' and British Institute… CONTINUE READING