Impact of sarA on antibiotic susceptibility of Staphylococcus aureus in a catheter-associated in vitro model of biofilm formation.

@article{Weiss2009ImpactOS,
  title={Impact of sarA on antibiotic susceptibility of Staphylococcus aureus in a catheter-associated in vitro model of biofilm formation.},
  author={Elizabeth C Weiss and Horace J. Spencer and Sonja J Daily and Brian D Weiss and Mark S Smeltzer},
  journal={Antimicrobial agents and chemotherapy},
  year={2009},
  volume={53 6},
  pages={2475-82}
}
Mutation of the staphylococcal accessory regulator (sarA) in Staphylococcus aureus limits but does not abolish the capacity of the organism to form a biofilm. As a first step toward determining whether this limitation is therapeutically relevant, we carried out in vitro studies comparing the relative susceptibility of an S. aureus clinical isolate (UAMS-1) and its isogenic sarA mutant (UAMS-929) in the specific context of a catheter-associated biofilm. The antibiotics tested were daptomycin… CONTINUE READING

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Factors contributing to the biofilm - deficient phenotype of Staphylococcus aureus sarA mutants

  • A. Toledo-Arana, B. Amorena, J. R. Penades
  • PLoS ONE
  • 2008

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