Impact of reactive oxygen species on spontaneous mutagenesis in Escherichia coli

@article{Sakai2006ImpactOR,
  title={Impact of reactive oxygen species on spontaneous mutagenesis in Escherichia coli},
  author={Akiko Sakai and Mari Nakanishi and Kaoru Okamoto Yoshiyama and Hisaji Maki},
  journal={Genes to Cells},
  year={2006},
  volume={11}
}
Reactive oxygen species (ROS) are potent oxidants that attack chromosomal DNA and free nucleotides, leading to oxidative DNA damage that causes genetic alterations. To avoid the ROS‐mediated mutagenesis, cells have elaborate mechanisms including powerful antioxidant components and repair pathways that eliminate oxidative DNA damage. Because of the effective anti‐mutagenic functions, it has been unclear to what extent the ROS contribute to spontaneous mutagenesis. Here we show that a significant… 
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Oxidative Stress.
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