Impact of protective IL-2 allelic variants on CD4+ Foxp3+ regulatory T cell function in situ and resistance to autoimmune diabetes in NOD mice.

@article{Sgouroudis2008ImpactOP,
  title={Impact of protective IL-2 allelic variants on CD4+ Foxp3+ regulatory T cell function in situ and resistance to autoimmune diabetes in NOD mice.},
  author={Evridiki Sgouroudis and Alexandre Albanese and Ciriaco A Piccirillo},
  journal={Journal of immunology},
  year={2008},
  volume={181 9},
  pages={6283-92}
}
Type I diabetes (T1D) susceptibility is inherited through multiple insulin-dependent diabetes (Idd) genes. NOD.B6 Idd3 congenic mice, introgressed with an Idd3 allele from T1D-resistant C57BL/6 mice (Idd3(B6)), show a marked resistance to T1D compared with control NOD mice. The protective function of the Idd3 locus is confined to the Il2 gene, whose expression is critical for naturally occurring CD4(+)Foxp3(+) regulatory T (nT(reg)) cell development and function. In this study, we asked whether… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
25 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 25 extracted citations

Similar Papers

Loading similar papers…