Impact of progesterone receptor on cell-fate decisions during mammary gland development.

@article{Shyamala2000ImpactOP,
  title={Impact of progesterone receptor on cell-fate decisions during mammary gland development.},
  author={G. Shyamala and X. Yang and R. Cardiff and E. Dale},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 7},
  pages={
          3044-9
        }
}
  • G. Shyamala, X. Yang, +1 author E. Dale
  • Published 2000
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
Mammary epithelium contains lineage-limited progenitors that give rise to cells that form distinct morphological structures, ducts vs. lobules, depending on the endocrine status of the female. Progesterone signaling through progesterone receptor (PR) is essential for lobulo-alveolar development that accompanies pregnancy, but not for ductal growth accompanying puberty. PR exists in two molecular forms, A and B, and an imbalance in the native ratio of the two isoforms can lead to alterations in… Expand
134 Citations
Progesterone Receptors in Mammary Gland Development and Tumorigenesis
  • 140
Establishing a Framework for the Functional Mammary Gland: From Endocrinology to Morphology
  • 290
A Reappraisal of Progesterone Action in the Mammary Gland
  • 45
  • PDF
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 23 REFERENCES
The progesterone receptor and its isoforms in mammary development.
  • 16
Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities.
  • 1,688
  • PDF
...
1
2
3
...