Impact of prior treatment and depth of response on survival in MM-003, a randomized phase 3 study comparing pomalidomide plus low-dose dexamethasone versus high-dose dexamethasone in relapsed/refractory multiple myeloma.

@article{Miguel2015ImpactOP,
  title={Impact of prior treatment and depth of response on survival in MM-003, a randomized phase 3 study comparing pomalidomide plus low-dose dexamethasone versus high-dose dexamethasone in relapsed/refractory multiple myeloma.},
  author={Jes{\'u}s Fernando San Miguel and Katja C. Weisel and Kevin W. Song and Michel Delforge and Lionel Karlin and Hartmut Goldschmidt and Philippe Moreau and Anne Banos and Albert Oriol and Laurent Garderet and Michele Cavo and Valentina Ivanova and Adr{\'i}an Alegre and Joaquin Martinez-Lopez and Christine I. Chen and Christoph Renner and Nizar Jacques Bahlis and Xin Yu and Terri Teasdale and Lars Axel Sternas and Christian J. D. Jacques and Mohamed H. Zaki and Meletios Athanasios Dimopoulos},
  journal={Haematologica},
  year={2015},
  volume={100 10},
  pages={1334-9}
}
Pomalidomide is a distinct oral IMiD(®) immunomodulatory agent with direct antimyeloma, stromal-support inhibitory, and immunomodulatory effects. The pivotal, multicenter, open-label, randomized phase 3 trial MM-003 compared pomalidomide + low-dose dexamethasone vs high-dose dexamethasone in 455 patients with refractory or relapsed and refractory multiple myeloma after failure of bortezomib and lenalidomide treatment. Initial results demonstrated significantly longer progression-free survival… CONTINUE READING
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Pomalidomide plus low - dose dexamethasone in relapsed or refractory multiple myeloma ( RRMM ) with deletion ( del ) 17 p and / or translocation t ( 4 ; 14 ) [ abstract 689 ]

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