Impact of plasma oxidized low-density lipoprotein removal on atherosclerosis.

  title={Impact of plasma oxidized low-density lipoprotein removal on atherosclerosis.},
  author={Yasushi Ishigaki and Hideki Katagiri and Junhong Gao and Tetsuya Yamada and Junta Imai and Kenji Uno and Yutaka Hasegawa and Keizo Kaneko and Takehide Ogihara and Hisamitsu Ishihara and Yuko Sato and Kenji Takikawa and Norihisa Nishimichi and Haruo Matsuda and Tatsuya Sawamura and Yoshitomo Oka},
  volume={118 1},
BACKGROUND Several clinical studies of statin therapy have demonstrated that lowering low-density lipoprotein (LDL) cholesterol prevents atherosclerotic progression and decreases cardiovascular mortality. In addition, oxidized LDL (oxLDL) is suggested to play roles in the formation and progression of atherosclerosis. However, whether lowering oxLDL alone, rather than total LDL, affects atherogenesis remains unclear. METHODS AND RESULTS To clarify the atherogenic impact of oxLDL, lectin-like… CONTINUE READING


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