Impact of phase I or phase II enzyme polymorphisms on lymphocyte DNA adducts in subjects exposed to urban air pollution and environmental tobacco smoke.

@article{Georgiadis2004ImpactOP,
  title={Impact of phase I or phase II enzyme polymorphisms on lymphocyte DNA adducts in subjects exposed to urban air pollution and environmental tobacco smoke.},
  author={Panagiotis Georgiadis and Nikolaos A Demopoulos and J. Rick Topinka and Georgia Stephanou and Melpomeni Stoikidou and Margarita Bekyrou and K Katsouyianni and Radim J. {\vS}r{\'a}m and Herman Autrup and Soterios A Kyrtopoulos},
  journal={Toxicology letters},
  year={2004},
  volume={149 1-3},
  pages={269-80}
}
Little is known about the impact of genetic variation on the genetic damage induced by urban air pollution or environmental tobacco smoke (ETS) in exposed populations. The levels of bulky DNA adducts ( 32P-postlabelling, nuclease P1 enrichment) and chromosomal aberrations were measured in lymphocytes of 194 non-smoking students living in the city of Athens, and the rural region of Halkida, Greece. In these individuals personal exposure to PAH was also measured. Furthermore, genetic… CONTINUE READING