Impact of perineural invasion in the pathologically N0 neck in oral cavity squamous cell carcinoma.

@article{Chinn2013ImpactOP,
  title={Impact of perineural invasion in the pathologically N0 neck in oral cavity squamous cell carcinoma.},
  author={Steven B. Chinn and Matthew E Spector and Emily Light Bellile and Jonathan McHugh and Thomas J Gernon and Carol R. Bradford and G T Wolf and Avraham Eisbruch and Douglas B. Chepeha},
  journal={Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery},
  year={2013},
  volume={149 6},
  pages={893-9}
}
OBJECTIVE Patients with oral cavity squamous cell carcinoma (OCSCC) undergo adjuvant radiation for pathologically high-risk features including positive nodal disease and extracapsular spread (ECS). In the absence of these high-risk features, our objective was to determine if perineural invasion (PNI) is an independent risk factor and if adjuvant radiation (XRT) improves disease control rates. STUDY DESIGN Historical cohort analysis. SETTING Tertiary university hospital. METHODS Eighty… CONTINUE READING
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