Impact of patching and atropine treatment on the child and family in the amblyopia treatment study.


OBJECTIVE To assess the psychosocial impact on the child and family of patching and atropine as treatments for moderate amblyopia in children younger than 7 years. METHODS In a randomized, controlled clinical trial, 419 children younger than 7 years with amblyopic eye visual acuity in the range of 20/40 to 20/100 were assigned to receive treatment with either patching or atropine at 47 clinical sites. After 5 weeks of treatment, a parental quality-of-life questionnaire was completed for 364 (87%) of the 419 patients. Main Outcome Measure Overall and subscale scores on the Amblyopia Treatment Index. RESULTS High internal validity and reliability were demonstrated for the Amblyopia Treatment Index questionnaire. The overall Amblyopia Treatment Index scores and the 3 subscale scores were consistently higher (worse) in the patching group compared with the atropine-treated group (overall mean, 2.52 vs 2.02, P<.001; adverse effects of treatment: mean, 2.35 vs 2.11, P =.002; difficulty with compliance: mean, 2.46 vs 1.99, P<.001; and social stigma: mean, 3.09 vs 1.84, P<.001, respectively). CONCLUSION Although the Amblyopia Treatment Index questionnaire results indicated that both atropine and patching treatments were well tolerated by the child and family, atropine received more favorable scores overall and on all 3 questionnaire subscales.

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@article{Holmes2003ImpactOP, title={Impact of patching and atropine treatment on the child and family in the amblyopia treatment study.}, author={Jonathan Holmes and Roy W Beck and Raymond T. Kraker and Stephen R. Cole and Michael X. Repka and Eileen E. Birch and Joost Felius and Stephen P. Christiansen and David K. Coats and Marjean Taylor Kulp}, journal={Archives of ophthalmology}, year={2003}, volume={121 11}, pages={1625-32} }