Impact of outdated gene annotations on pathway enrichment analysis

@article{Wadi2016ImpactOO,
  title={Impact of outdated gene annotations on pathway enrichment analysis},
  author={Lina Wadi and Mona Meyer and Joel Weiser and Lincoln D. Stein and J{\"u}ri Reimand},
  journal={Nature Methods},
  year={2016},
  volume={13},
  pages={705-706}
}
To the Editor: Pathway enrichment analysis is a common technique for interpreting gene lists derived from high-throughput experiments1. Its success depends on the quality of gene annotations. We analyzed the evolution of pathway knowledge and annotations over the past seven years and found that the use of outdated resources has strongly affected practical genomic analysis and recent literature: 67% of ~3,900 publications we surveyed in 2015 referenced outdated software that captured only 26% of… 

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