Impact of oral vancomycin on gut microbiota, bile acid metabolism, and insulin sensitivity.

  title={Impact of oral vancomycin on gut microbiota, bile acid metabolism, and insulin sensitivity.},
  author={Anne Vrieze and Carolien Out and Susana Fuentes and Lisanne D Jonker and Isaie J Reuling and Ruud S. Kootte and Els van Nood and Frits Holleman and Max Knaapen and Johannes Anthonius Romijn and Maarten R. Soeters and Ellen E Blaak and Geesje M. Dallinga-Thie and Dorien Reijnders and Mari{\"e}tte Theodora Ackermans and Mireille J Serlie and Filip Krag Knop and Jenst J Holst and Claude van der Ley and Ido P. Kema and Erwin G. Zoetendal and Willem M de Vos and Joost B. L. Hoekstra and Erik S. G. Stroes and Albert K. Groen and Max Nieuwdorp},
  journal={Journal of hepatology},
  volume={60 4},
BACKGROUND & AIMS Obesity has been associated with changes in the composition and function of the intestinal microbiota. Modulation of the microbiota by antibiotics also alters bile acid and glucose metabolism in mice. Hence, we hypothesized that short term administration of oral antibiotics in humans would affect fecal microbiota composition and subsequently bile acid and glucose metabolism. METHODS In this single blinded randomized controlled trial, 20 male obese subjects with metabolic… CONTINUE READING
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