Impact of omeprazole on the plasma clearance of methotrexate

  title={Impact of omeprazole on the plasma clearance of methotrexate},
  author={Tony Reid and Alan R. Yuen and Marbel Catolico and Robert W. Carlson},
  journal={Cancer Chemotherapy and Pharmacology},
Omeprazole inhibits the gastric hydrogen pump and is an effective treatment for peptic ulcers. Methotrexate is a chemotherapeutic agent that inhibits dihydrofolate reductase and is eliminated by a hydrogen-ion-dependent mechanism in the kidney. We present evidence that omeprazole inhibits methotrexate clearance and may result in potentially toxic methotrexate levels. 

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The pharmacology of methotrexate

  • E Olsen
  • J Am Acad Dermato125:306
  • 1991
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