Impact of nuclear Piwi elimination on chromatin state in Drosophila melanogaster ovaries

@inproceedings{Klenov2014ImpactON,
  title={Impact of nuclear Piwi elimination on chromatin state in Drosophila melanogaster ovaries},
  author={Mikhail S. Klenov and Sergey A. Lavrov and Alina P. Korbut and Anastasia D. Stolyarenko and Evgeny Y. Yakushev and Michael Reuter and Ramesh S Pillai and Vladimir A. Gvozdev},
  booktitle={Nucleic acids research},
  year={2014}
}
The Piwi-interacting RNA (piRNA)-interacting Piwi protein is involved in transcriptional silencing of transposable elements in ovaries of Drosophila melanogaster. Here we characterized the genome-wide effect of nuclear Piwi elimination on the presence of the heterochromatic H3K9me3 mark and HP1a, as well as on the transcription-associated mark H3K4me2. Our results demonstrate that a significant increase in the H3K4me2 level upon nuclear Piwi loss is not accompanied by the alterations in H3K9me3… CONTINUE READING
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