Impact of mutations at residue I223 of the neuraminidase protein on the resistance profile, replication level, and virulence of the 2009 pandemic influenza virus.

@article{Pizzorno2012ImpactOM,
  title={Impact of mutations at residue I223 of the neuraminidase protein on the resistance profile, replication level, and virulence of the 2009 pandemic influenza virus.},
  author={Andr{\'e}s Pizzorno and Yacine Abed and Xavier Bouhy and {\'E}dith Beaulieu and Corey P. Mallett and Rupert J. M. Russell and Guy Boivin},
  journal={Antimicrobial agents and chemotherapy},
  year={2012},
  volume={56 3},
  pages={1208-14}
}
Amino acid substitutions at residue I223 of the neuraminidase (NA) protein have been identified in 2009 pandemic influenza (pH1N1) variants with altered susceptibilities to NA inhibitors (NAIs). We used reverse genetics and site-directed mutagenesis to generate the recombinant A/Québec/144147/09 pH1N1 wild-type virus (WT) and five (I223R, I223V, H275Y… CONTINUE READING